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Study Links Inflammation of Intra-Abdominal Fat and the Ill-Effects of Obesity

Study Links Inflammation of Intra-Abdominal Fat and the Ill-Effects of Obesity

July 11, 2008

Medical Research, Press Releases

BEER-SHEVA, Israel – June 28, 2007 – Researchers at Ben-Gurion University of the Negev (BGU) led by Drs. Assaf Rudich, Iris Shai and Prof. Nava Bashan, in conjunction with Soroka University Medical Center (led by Dr. Ilana Harman-Boehm) and colleagues from the University of Leipzig, Germany, have discovered a possible link between diseases caused by obesity and fat tissue inflammation in the abdominal area of the body.


Each Center’s research programs obtained paired biopsies from intra-abdominal and subcutaneous (under the skin) fat taken from patients undergoing abdominal surgery.


Researchers demonstrated that fatty tissue collected within the abdomen attracts inflammatory cells of the immune system to a greater degree than the subcutaneous fat.  The number of these cells increases in people suffering from obesity, specifically those whose fat accumulation is found primarily in the abdominal cavity.  The research has found a correlation between the degree of intra-abdominal fat inflammation and the increased risk of developing type-2 diabetes and heart disease.

The researchers’ discoveries were published in June in two American Endocrine Society journals – Endocrinology, and the Journal of Clinical Endocrinology and Metabolism.


When comparing the two types of fatty tissues, as well as obese versus lean people, researchers were able to pinpoint two specific inflammation response signals that were increased in the intra-abdominal fat of the obese patients.  These findings provide new insight to the possible cause and effect in this situation, and may open new therapeutic avenues for treatment.  


The research was funded by The Russell Berrie Foundation and D-Cure Diabetes Care in Israel, by The Israeli Foundation for the Study of Diabetes, and by the Israel Science Foundation. 

About American Associates, Ben-Gurion University of the Negev

American Associates, Ben-Gurion University of the Negev (AABGU) plays a vital role in sustaining David Ben-Gurion’s vision: creating a world-class institution of education and research in the Israeli desert, nurturing the Negev community and sharing the University’s expertise locally and around the globe. As Ben-Gurion University of the Negev (BGU) celebrates its 50th birthday this year, AABGU imagines a future that goes beyond the walls of academia. It is a future where BGU invents a new world and inspires a vision for a stronger Israel and its next generation of leaders. Together with supporters, AABGU will help the University foster excellence in teaching, research and outreach to the communities of the Negev for the next 50 years and beyond.

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