Similarities Between Leukemia and AIDS Discovered
August 24, 2015
Breakthrough Could Be Key to Finding Clinical Solution that Prevents HIV and Destroys the Virus
Researchers at Ben-Gurion University of the Negev (BGU) have made a significant breakthrough, discovering similarities between Leukemia and HIV that might hold the key to developing a clinical solution to prevent and destroy the virus.
“Similar to what happens with the HIV virus when it enters a chronic state, reproduction mechanisms control the expression of the genes responsible for hematopoietic STEM cells – the first cells that develop,” says Dr. Ran Taube, of BGU’s Shraga Segal Department of Microbiology and Immunology.
“This research is based on the assumption that damage to the mechanisms of expression and reproduction of the viral genome is responsible for the accumulation of the latent HIV virus and leads to the chronic disease condition.”
Dr. Taube’s team, in collaboration with Dr. Uri Rubio of Soroka University Medical Center, is seeking innovative ways to “wake up” the virus from its silent active state, while at the same time applying anti-retrovirals to essentially eradicate the virus completely.
“Until now, the medical community researchers had very limited information on the existence of a connection between AIDS, caused by the HIV virus, and a rare blood cancer, known as Mixed Lineage Leukemia (MLL),” explains Dr. Taube.
“MLL, found mostly in children, hinders blood system cell development.” Dr. Taube’s research detects mechanisms of action that are similar to the development of the blood cancer MLL.
Although, in recent years, AIDS has been effectively treated with anti-retroviral medications, these do not prevent infections, so their efficacy is limited. Also, there are a small number of inactive, latent viral particles found in the body that are not affected by the anti-retroviral drugs. These viruses are hidden in the body, can effectively avoid the immune response, and at any moment can multiply and infect new cells.
There is still no vaccine and no treatment has been found to prevent the spread of the HIV virus and the number of people who are infected with the virus continues to rise each year.
The study was funded in part by the American Leukemia Research Foundation.
About American Associates, Ben-Gurion University of the Negev
American Associates, Ben-Gurion University of the Negev (AABGU) plays a vital role in sustaining David Ben-Gurion’s vision: creating a world-class institution of education and research in the Israeli desert, nurturing the Negev community and sharing the University’s expertise locally and around the globe. As Ben-Gurion University of the Negev (BGU) turns 50 this year, AABGU imagines a future that goes beyond the walls of academia. It is a future where BGU invents a new world and inspires a vision for a stronger Israel and its next generation of leaders. Together with supporters, AABGU will help the University foster excellence in teaching, research and outreach to the communities of the Negev for the next 50 years and beyond. Visit vision.aabgu.org to learn more.
A. Lavin Communications