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BGU Student Team Wins Competition for Cancer Therapy

BGU Student Team Wins Competition for Cancer Therapy

September 30, 2015

Leadership, Awards & Events, Medical Research, Press Releases

The student team from Ben-Gurion University of the Negev has just won the Best Health and Medicine Project category in the prestigious 12th Annual iGEM 2015 Giant Jamboree (International Genetically Engineered Machine) competition with their cutting-edge biological cancer therapy called “Boomerang.” Click here for website and video.

students with award

2015 iGEM team with supervisors Dr. Efrat Forti and Dr. Emil Ruvinov (standing, second and third from left) in Boston with their three awards

The winners were announced at the Awards Gala on Monday, September 28 at the Hynes Auditorium in Boston. iGEM is considered one of the most important ventures in the global sphere of science.  Nearly 4,600 students competed in this year’s event held September 24-28. Projects span a broad range across 15 different tracks — including health and medicine, energy, environment, food and nutrition, manufacturing, and others.

The BGU project Boomerang is based on advanced methods of genetic engineering and synthetic biology. It has many applications that rely on the special characteristics of cancer cells to identify and alter cells as well as treat the disease at the molecular level. As a cancer therapy, Boomerang works as a modular system, which recognizes cancer cells at a high level of specificity. It can cause disruption of genes essential for cancer survival or activate suicide genes so that the cancer or tumor kills itself.

Boomerang can also produce color proteins for cancer cell detection so that the edges of a tumor are visible to ensure complete surgical removal. The name “Boomerang” mirrors the actions in which the synthetic system uses cancer cells’ own genetic alterations against them.

“Most treatments cannot distinguish precisely enough between cancer and healthy cells,” according to the BGU iGEM team website. “Low specificity means higher toxicity and high rate of adverse effects. The BGU Boomerang system can be potentially designed according to unique characteristics of a patient’s tumor, paving the way to personalized medicine. We believe our strategy demonstrated in the winning prototype/proof-of-concept studies can change the approach to cancer treatments.”

3 awardsIn addition to winning the grand prize in the Best Health and Medicine Project in the “overgraduate” category (graduate level), the BGU team was a first runner-up in the overall competition, the first Israeli team to reach this level in iGEM. Lastly, the BGU team also won the Best New Basic Part Award for developing and submitting the best new functional DNA sequence.

“The University is so proud to have succeeded in this prestigious competition, which includes the best and brightest students in the synthetic biology field,” says Prof. Smadar Cohen, team leader and a member of the BGU Avram and Stella Goldstein-Goren Department of Biotechnology Engineering.

“Our success in the competition shows tremendous student dedication and excellent heterogeneous cross collaboration between students studying various subjects that include biotechnology, biology, economics, engineering, medicine, neuroscience and cognition, as well as political science,” says Cohen.

The BGU Student Team members who are pursuing a diverse range of degrees include: Shai Duchin, Bar Gazit, Dafna Goldman, Shalev Goldfarb, Shoham Rigbi, Adi Stein, Vlad Shumeiko, and Ori Zelichov. In addition to Prof. Cohen, the two team faculty advisors who accompanied the students were Dr. Emil Ruvinov and Dr. Efrat Forti, also from the BGU Department of Biotechnology Engineering.

“Much more than an annual student competition, the iGEM Giant Jamboree is also an international incubator for the synthetic biology industry that has spun out more than 20 competition projects into new startups,” says Randy Rettberg, iGEM Foundation president.

“With a spotlight on innovation, the iGEM Giant Jamboree also is about collaboration and giving back. iGEM competition teams submit biological parts from their projects to the Registry of Standard Biological Parts in a cycle that helps tomorrow’s iGEM teams and research labs,” says Rettberg.

About the iGEM Foundation

The iGEM Foundation is dedicated to education and competition, advancement of synthetic biology, and the development of open community and collaboration. iGEM, the International Genetically Engineered Machine Competition, inspires future synthetic biologists by hosting high school and collegiate level competitions in synthetic biology. iGEM also maintains the Registry of Standard Biological Parts with over 20,000 specified genetic parts—the world’s largest collection of BioBricks, open source DNA parts. Originally an MIT program, iGEM today is an independent, nonprofit organization based in Cambridge, Massachusetts.

About American Associates, Ben-Gurion University of the Negev

American Associates, Ben-Gurion University of the Negev (AABGU) plays a vital role in sustaining David Ben-Gurion’s vision: creating a world-class institution of education and research in the Israeli desert, nurturing the Negev community and sharing the University’s expertise locally and around the globe. As Ben-Gurion University of the Negev (BGU) celebrates its 50th birthday this year, AABGU imagines a future that goes beyond the walls of academia. It is a future where BGU invents a new world and inspires a vision for a stronger Israel and its next generation of leaders. Together with supporters, AABGU will help the University foster excellence in teaching, research and outreach to the communities of the Negev for the next 50 years and beyond.

Media Contact:
Andrew Lavin
A. Lavin Communications